Er and pr breast cancer

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Not all breast cancers are the same. Understand what type of breast cancer you have and how it differs from other types of breast cancer. Once you've been diagnosed with breast cancer, your doctor will review your pathology report and the results of any imaging tests to understand the specifics of your tumor.

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Your pathology report will include the results of a hormone receptor assay, a test that tells you whether or not the breast cancer cells have receptors for the hormones estrogen and progesterone. Hormone receptors are proteins — found in and on breast cells — that pick up hormone signals telling the cells to grow. This suggests that the cancer cells, like normal breast cells, may receive signals from estrogen that could promote their growth.

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Skip to Content. To help doctors give their patients the best possible care, the American Society of Clinical Oncology ASCO and the College of American Pathologists CAP developed evidence-based recommendations to improve the accuracy of testing for estrogen and progesterone receptors for breast cancer. Cancer cells with these receptors depend on estrogen and related hormones, such as progesterone, to grow.

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Background: Estrogen and Progesterone receptors are found in breast cancer cells that depend on estrogen and related hormones to grow. These are steroidal nuclear type of receptors. The most common method currently used to test a tumor for estrogen and progesterone receptors is immunohistochemistry or IHC.

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Estrogen receptor-positive ER-positive breast cancer is the most common type of breast cancer diagnosed today. According to the American Cancer Societyabout 2 out of every 3 cases of breast cancer are hormone receptor-positive. Most of these cases are ER-positive, meaning that there are estrogen receptors on the surface of the cell that bind to estrogen.

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Breast cancer cells taken out during a biopsy or surgery will be tested to see if they have certain proteins that are estrogen or progesterone receptors. When the hormones estrogen and progesterone attach to these receptors, they fuel the cancer growth. Cancers are called hormone receptor-positive or hormone receptor-negative based on whether or not they have these receptors proteins.

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Hormone receptor tests are both prognostic and predictive. Hormone receptors also provide information about treatment options. Hormone therapies slow or stop cancer's growth by changing the hormonal milieu.

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These cancer cells have special proteins inside, called hormone receptors. When hormones attach to hormone receptors, the cancer cells with these receptors grow. A pathologist determines the hormone receptor status by testing the tumor tissue removed during a biopsy.

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This summary table contains detailed information about research studies. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. Learn how to read a research table.

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