Silicone breast implants and antibodies

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The world's first wiki where authorship really matters Nature Genetics, Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.

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In a turnabout, the Dow Corning Corporation reported today that new studies on laboratory rats showed that the silicone gel used in breast implants was not inert, and in fact had been found to be a strong irritant of the immune system, at least in animals. More than one million American women have received silicone-gel implants over the last 30 years. Dow Corning estimates three-quarters of them received its products.

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Toon Nederlands. Display English. Detection of antipolymer antibodies APA in serum of women with silicone breast implants.

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To use a new immunologic assay to evaluate antipolymer antibody APA levels among women with silicone breast implants SBIs. The women underwent blood tests, including an APA test, a clinical examination, and an interview focusing on rheumatic complaints. Blood samples were tested blindly. The majority of women with SBIs had mild rheumatic complaints, and the severity of their symptoms was not related to APA levels.

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The most common cosmetic plastic surgery procedure is Breast augmentationwithperformed in The FDA approved silicone breast implants in The approval was based on only years of research.

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Skip to search form Skip to main content. Silicate antibodies in women with silicone breast implants: development of an assay for detection of humoral immunity. Ojo-Amaize and Melkon S.

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Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Systemic sclerosis SSc is believed to be caused by a complex interplay between genetic factors and environmental influences.

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The most common complication of silicone breast implants is capsular contracture massive scar formation around the implant. We postulate that capsular contracture is always a sequel to inflammatory processes, with both innate and adaptive immune mechanisms participating. In general, fibroblasts and macrophages have been used as cell types to evaluate in vitro the biocompatibility of breast implant surfaces. Moreover, also T cells have been found at the implant site at the initial stage of fibrous capsule formation.

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The study, published in the widely cited international medical journal the Lancet, describes a newly developed blood test for antibodies that the researchers say are produced in response to leaking silicone. The researchers claim their study provides the first medical evidence to back contentions that silicone breast implants cause an unusual disease. The researchers report that a survey of 95 women with implants found that the antibodies were much more common among women with serious illnesses than among those with just mild symptoms.

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In the past decade, a number of independent studies have examined whether silicone gel-filled breast implants are associated with connective tissue disease or cancer. Must be cautiously interpreted. Diverse immunologic abnormalities have been described in women who received silicone breast implants.

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