Phthalates and sexual maturation

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Endocrine disrupting chemicals EDCs adversely affect animals and human beings. This attracted the researchers in the previous decade to explore the possible association of these chemicals. However, among various studies, very limited data is available to explain the link between EDCs and reproductive tract outcome.

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Not a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. To safeguard public health, the US Environmental Protection Agency EPA must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making.

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Chan School of Public Health. Phthalates are a group of man-made chemicals often added to plastics and vinyls to make them more flexible, soft, and durable. They are used in a wide variety of consumer products.

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Home People John Meeker. Deborah Watkins. Monica Silver.

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Human exposure to phthalates, which are endocrine disrupting chemicals EDCsis ubiquitous in the human environment because of their wide use in plastics and other common consumer products. General populations are exposed to phthalates via ingestion, inhalation, dermal absorption, and medical treatment. The potential consequences of human exposure to phthalates have raised concerns in the general population and have been widely studied in susceptible subjects, such as pregnant women, infants, and children.

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While these connections aid understanding about these issues, they represent a simplified view of the field of endocrine disruption. The endocrine system can be regarded as a number of interconnecting and interacting axes. The major regulator of the mature reproductive system is the hypothalamo—pituitary—gonadal HPG axis that functions as a classical negative feedback system.

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Skip to search form Skip to main content. Evidence suggests that phthalate and BPA exposure alters steroid hormone levels in adults, while in utero exposure has been associated with altered fetal reproductive development in boys. However, the impact of exposure during distinct critical windows of in utero development on hormone concentrations and sexual maturation during the pubertal transition has not been examined.

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The age of menarche has been associated with metabolic and cardiovascular disease, as well as cancer risk. The decline in menarcheal age over the past century may be partially attributable to increased exposure to endocrine disrupting chemicals EDCs. We assessed the influence of 26 phenol and phthalate biomarkers on the timing of menarche in a longitudinal cohort of Chilean girls.

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There is recent evidence that exposure to bisphenol A BPA and phthalates, endocrine disrupting chemicals used in plastics, personal care products, and other consumer goods, may be associated with adverse effects on fetal and child growth and development. This is of particular concern since most people, including pregnant women and children, are roufinely exposed to these compounds on a daily basis. Despite the evidence that exposures to BPA and phthalates are widespread among the general population and increasing concern for human health impacts associated with exposure, human studies that have investigated these relationships remain limited.

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